| He was born in Burma, which is now known as Myanmar. |
| Due to political instability in Burma in 1960, his family moved to Rajkot. |
| His father founded a trading firm named Rasiklal & Sons, and Rupani is a partner in the firm. |
| Rupani also worked as a stockbroker. |
| He began his political career as a student activist of Akhil Bhartiya Vidyarthi Parishad (ABVP), the student political wing of BJP. |
| In 1971, he entered serious politics by joining RSS and Jan Sangh. |
| During the Emergency in 1976, he spent 11 months in the jails of Bhuj and Bhavnagar. |
| From 1978 to 1981, he served as a Pracharak of RSS. |
| In 2006, Rupani was appointed as the Chairman of Gujarat Tourism. |
| After Vajubhai Vala resigned as the MLA from Rajkot West in August 2014, BJP nominated Vijay Rupani to contest the seat, and he won the by-poll on 9 October 2014. |
| He became the BJP President of Gujarat on 19 February 2016 and served until August 2016. |
| As the only cabinet minister to have been jailed during the Emergency, he was part of the Gujarat Government's cabinet in 2016. |
| After serving as a corporator and Mayor of Rajkot, he became a member of the Rajya Sabha. |
| He chaired the Manifesto Committee during Keshubhai Patel’s regime. |
| During Narendra Modi's tenure as Chief Minister of Gujarat, he held the positions of chairman of Gujarat Finance Board and general secretary of BJP’s Gujarat Unit. |
| In Anandiben Patel’s government, he was the cabinet minister of Transport, water supply, labour, and employment. |
| Vijay Rupani initiated the Pujit Rupani Memorial Trust for charity in memory of his late son, Pujit. |