| Karim Janat began playing cricket in his childhood, inspired by his elder brother Asghar Afghan, who captained the Afghanistan cricket team. |
| He participated in domestic cricket and represented Afghanistan at the 2016 Under-19 World Cup. |
| In November 2020, his brother Asghar Afghan got engaged for the second time, having a son and four daughters from his first marriage. |
| In November 2021, he secured a sponsorship deal with Sporoot Sports. |
| During the 2023 Four-Day Tournament, he made 561 runs at an impressive average of 140.25, scoring two centuries and four fifties while taking 18 wickets, ranking as the third highest wicket-taker. |
| Karim represented Afghanistan in the T20 World Cup editions of 2021 and 2024. |
| He was part of the Afghanistan team that won a silver medal at the 19th Asian Games in Hangzhou, China. |
| In a T20I match against Bangladesh on 14 July 2023, he achieved a hat-trick, although Afghanistan lost the match. |
| On 24 June 2024, during a T20 World Cup match against Bangladesh, he had an on-pitch incident with Rashid Khan, refusing a second run, leading to Khan expressing frustration. |
| In October 2024, he played a crucial role in Afghanistan's victory at the Emerging Asia Cup. |
| During the 2024 LPL auction, Dambulla Thunders purchased him for $80,000. |
| In the 2025 IPL auction, he was acquired by Gujarat Titans for his base price of Rs 75 lakhs. |
