| Karthi spent his childhood in Chennai. |
| During his childhood, he found inspiration in the movies of Jackie Chan and Bruce Lee, which fueled his passion for acting. |
| He commenced his career as an engineering consultant in Chennai after completing his graduation, eventually pursuing further studies in New York. |
| Upon his return to India, he worked as an assistant director under the guidance of director Mani Ratnam. |
| In 2010, he was appointed as the brand ambassador for Bharti Airtel South India. |
| Karthi has showcased his vocal talents in several Tamil songs. |
| In 2011, he took on the role of a cause ambassador to raise awareness about lysosomal storage disease. |
| His presence can be seen in television advertisements for various brands. |
| In 2015, he was elected as the treasurer of the Nadigar Sangam. |
| An annual tradition sees Karthi visiting orphanages on his birthday, contributing funds for their support. |
| On his 31st birthday, he inaugurated the NGO Makkal Nala Mandram. |
| Karthi is known for adopting a white tiger cub at Vandalur Zoo. |
| Expressing interest in aviation, he has voiced his aspiration to learn flying. |
| In 2019, Karthi openly criticized actress Kasturi Shankar for mocking his father. |
| Setting a stance against on-screen smoking, he mentioned in 2020 that he has never partaken in a smoking scene. |
| To support a Chennai-based organization, he auctioned his cherished guitar in 2022. |
| Karthi's 25th movie 'Japan' in 2023 featured his acting skills and his rendition of a Telugu song for the film. |
