| She was born into a Mudaliar family in Tiruvarur district of Tamil Nadu. |
| Her family later relocated to Mannargudi. |
| She married M. Natarajan, who was a temporary Public Relation Officer in the Tamil Nadu Government. |
| In 1976, her husband lost his job during the Internal Emergency enforced by Prime Minister Indira Gandhi, leading them to sell or pawn their jewels for livelihood. |
| To supplement their income, Sasikala started a video renting business. |
| Her husband had a connection with V S Chandralekha, the District Collector of Cuddalore, who was linked to M. G. Ramachandran, the Chief Minister of Tamil Nadu then. |
| V S Chandralekha introduced Sasikala Natarajan to Jayalalithaa, and they developed a close relationship. |
| In 1995, Jayalalithaa organized an extravagant marriage for her foster son V. N. Sudhakaran, Sasikala Natarajan's nephew. |
| Jayalalithaa faced criticism for the lavish spending at the wedding. |
| After Sasikala entered Jayalalithaa's Poes Garden Residence, she was accused of misappropriating funds on Jayalalithaa's behalf. |
| On 19 December 2011, Jayalalithaa expelled Sasikala from AIADMK, but she was reinstated on 31 March 2012. |
| Following Jayalalithaa's death on 5 December 2016, Sasikala was poised to succeed her as AIADMK General Secretary. |
| She became the 2nd woman to lead AIADMK after Jayalalithaa when appointed as General Secretary on 31 December 2016. |
